李琦，女，工学博士，高级实验师，南京林业大学林产化学加工工程专业毕业。2013年9月参加工作，2022年10月调入轻工与食品学院食品科学与工程系。主要从事糖苷水解酶的挖掘、改造、重组菌的表达及天然活性物质的催化转化方面的研究。目前作为骨干参与国家重点研发计划项目课题1项，国家自然科学基金2项，横向课题2项。在国内外权威期刊发表学术论文20余篇，其中SCI文章10篇，EI文章1篇，并获得授权专利4项。先后指导本科生参加国际互联网加竞赛1项，并获一等奖；指导学生参加国家级生命科学竞赛3项，均获得三等奖及以上；指导本科生省级大创项目1项，并验收优秀。

糖苷水解酶的挖掘、基因改造

天然活性物质的催化转化

[1]十四五国家重点研发计划项目课题--竹源活性成分定向转化富集技术与示范（366.60万元，课题秘书）2022.11-2027.10

[2]十三五国家重点研发项目课题任务--典型林源黄酮和萜类物质生物修饰关键技术及其药理活性的研究（84.00万元，2/10）2016.07-2020.12

[3]国家自然科学基金面上项目--嗜热鼠李糖苷酶底物特异性机制及其定向改（76.80万元，2/10）2016.01-2019.12

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[2]Li, Q., Wang, L.,  Fang, X., Zhao, L., (2022).Highly Efficient Biotransformation of Notoginsenoside R1 into Ginsenoside Rg1 by Dictyoglomus thermophilum β-xylosidase Xln-DT. Journal of Microbiology and Biotechnology, 32(4): 447-457.

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[6] Li, Q.,  Jiang, Y.,  Tong, X.,  Zhao, L., &  Pei, J. . (2021). Co-production of xylooligosaccharides and xylose from poplar sawdust by recombinant endo-1,4-β-xylanase and β-xylosidase mixture hydrolysis. Frontiers in Bioengineering and Biotechnology, 8, 637397.

[7] Li, Q., Jiang, Y., Tong, X., Pei, J., Xiao, W., Wang, Z., Zhao, L.,(2020) .Cloning and characterization of the β-xylosidase from dictyoglomus turgidum for high efficient biotransformation of 10-deacetyl-7-xylosltaxol. Bioorganic Chemistry, 94.

[8] Li, Q., Wu, T., Duan, Y., Pei, J., Zhao, L.,(2019). Improving the thermostability and ph stability of aspergillus niger xylanase by site-directed mutagenesis. Applied biochemistry and microbiology, 55(2).

[9] Li, Q., Wu, T., Zhao, L., Pei, J., Wang, Z., Xiao, W.,(2018). Highly efficient biotransformation of astragaloside iv to cycloastragenol by sugar-stimulated β-glucosidase and β-xylosidase from dictyoglomus thermophilum. Journal of Microbiology & Biotechnology.

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