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教师介绍
李琦  (食品科学与工程系)

基本信息

职务:

职称:高级工程师

地址:9D303

邮箱:amanadahere@sina.com

个人简介:

李琦,女,工学博士,高级实验师,南京林业大学林产化学加工工程专业毕业。2013年9月参加工作,2022年10月调入轻工与食品学院食品科学与工程系。主要从事糖苷水解酶的挖掘、改造、重组菌的表达及天然活性物质的催化转化方面的研究。目前作为骨干参与国家重点研发计划项目课题1项,国家自然科学基金2项,横向课题2项。在国内外权威期刊发表学术论文20余篇,其中SCI文章10篇,EI文章1篇,并获得授权专利4项。先后指导本科生参加国际互联网加竞赛1项,并获一等奖;指导学生参加国家级生命科学竞赛3项,均获得三等奖及以上;指导本科生省级大创项目1项,并验收优秀。

主要研究方向:

糖苷水解酶的挖掘、基因改造

天然活性物质的催化转化

 

研究课题情况:

[1]十四五国家重点研发计划项目课题--竹源活性成分定向转化富集技术与示范(366.60万元,课题秘书)2022.11-2027.10

[2]十三五国家重点研发项目课题任务--典型林源黄酮和萜类物质生物修饰关键技术及其药理活性的研究(84.00万元,2/10)2016.07-2020.12

[3]国家自然科学基金面上项目--嗜热鼠李糖苷酶底物特异性机制及其定向改(76.80万元,2/10)2016.01-2019.12

代表性成果:

[1] Zhang, S. ,  Lu, C. ,  Cao, S. ,  Li, Q. ,  Wu, G. , &  Zhao, L. . (2023). Efficient production of icariin and baohuoside i fromepimedium foliumflavonoids by fungalα-l-rhamnosidase hydrolysing regioselectively the terminal rhamnose of epimedin c. Biotechnology for Biofuels and Bioproducts, 16(1).

[2]Li, Q., Wang, L.,  Fang, X., Zhao, L., (2022).Highly Efficient Biotransformation of Notoginsenoside R1 into Ginsenoside Rg1 by Dictyoglomus thermophilum β-xylosidase Xln-DT. Journal of Microbiology and Biotechnology, 32(4): 447-457.

[3] Li, Q., Ge, L., Zheng, D., Zhang, X., Zhao, L.,(2022). Screening and characterization of a GH78 α-L-rhamnosidase from Aspergillus terreus and its application in the bioconversion of icariin to icaritin with recombinant β-glucosidase. Enzyme and Microbial Technology, 153: 109940.

[4] Li, Q.,  Chai, C. ,  Du, Y. ,  Cai, J. , &  Zhao, L. . (2022).  Recombinant laccase production optimization in pichia pastoris by  response surface methodology and its application in the biodegradation  of octyl phenol and 4-tert-octylphenol. Catalysis Letters(4), 152.

[5] Li, Q.,  Tong, X. ,  Jiang, Y. ,  Li, D. , &  Zhao, L. . (2021). Improvements in xylose stability and thermalstability of gh39 β-xylosidase from dictyoglomus thermophilum by site-directed mutagenesis and insights into its xylose tolerance mechanism. Enzyme and Microbial Technology, 151, 109921.

[6] Li, Q.,  Jiang, Y.,  Tong, X.,  Zhao, L., &  Pei, J. . (2021). Co-production of xylooligosaccharides and xylose from poplar sawdust by recombinant endo-1,4-β-xylanase and β-xylosidase mixture hydrolysis. Frontiers in Bioengineering and Biotechnology, 8, 637397.

[7] Li, Q., Jiang, Y., Tong, X., Pei, J., Xiao, W., Wang, Z., Zhao, L.,(2020) .Cloning and characterization of the β-xylosidase from dictyoglomus turgidum for high efficient biotransformation of 10-deacetyl-7-xylosltaxol. Bioorganic Chemistry, 94.

[8] Li, Q., Wu, T., Duan, Y., Pei, J., Zhao, L.,(2019). Improving the thermostability and ph stability of aspergillus niger xylanase by site-directed mutagenesis. Applied biochemistry and microbiology, 55(2).

[9] Li, Q., Wu, T., Zhao, L., Pei, J., Wang, Z., Xiao, W.,(2018). Highly efficient biotransformation of astragaloside iv to cycloastragenol by sugar-stimulated β-glucosidase and β-xylosidase from dictyoglomus thermophilum. Journal of Microbiology & Biotechnology.

[10] Li, Q., Wu, T., Qi, Z., Zhao, L., Pei, J., Tang, F.,(2018). Characterization of a novel thermostable and xylose-tolerant gh 39 β-xylosidase from dictyoglomus thermophilum. Bmc Biotechnology, 18(1), 29.